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DBSP Graduate Students

David Goodwin

David Goodwin

PhD Candidate, Parisitology
Department of Biomedical Sciences & Pathobiology
Graduate Advisor: Dr. David Lindsay

e-mail: dagoodwi@vt.edu


Education

1996 BS. Animal Science
University of New Hampshire

Brief Bio

I am interested in coccidail parasites, long walks on the beach, Whitewater boating, hanging out with my coonhound and wife.


Research Project Involvement

  • PDGF role in venous ulcers– Determine the role PDGF has in venous ulcers MAPK pathway in venous ulcers – Determine which step of the MAPK pathway is interrupted in venous ulcers The role IRF-1 plays in MRL-Lpr knock out mice – Examine ds-DNA deposition and Immune alteration in IRF-1 knock out mice
  • Uses of histone deacetylase (HDAC) inhibitors to prevent Lupus like symptoms - Uses of several HDAC compounds in a mouse models
  • Prevalence of Encephalitozoon cuniculi in dogs and horses – Screened horse and dog samples by Immuno-Fluorescent assay and Direct Aggultination
  • Develop and improve In vitro cultivation of Encephalitozoon cuniculi – Increase growth yields of Microsporidean parasites through in vitro and in vivo models
  • Uses of different histone deacetylases and Valproic acid to treat toxoplasmosis - Several HDAC inhibitors and Valproic acid were tested in vivo for activity against acute and chronic toxoplasmosis
  • The role congenital toxoplasmosis plays in neuro transmitter levels and behavioral alterations in mice – Currently in progress

Professional Experience

  • Research assistant, Boston Medical Center, Boston, Mass
  • Research technician, Virginia tech Vet Med, Blacksburg, VA
  • Grad Student, Virginia Tech, Department of Biomedical Sciences and Pathobiology, Blacksburg, VA

Professional Memberships

  • American Association of Veterinary Parasitologists
  • Southern Society of Parasitologists
  • Association of Southern Biologists

Awards

  • 1st place at VCOM research days poster competition
  • American Association of Veterinary Parasitologists – Companion Animal Parasite Council zoonotic disease award
  • American Association of Veterinary Parasitologist Student Travel Grant – To present current research at the national conference in Hawaii, Washington D.C., Louisiana
  • American Association of Veterinary Parasitologist Student representative

Papers

  • Lindsay DS, Goodwin DG, Zajac AM, Cortés-Vecino JA, Gennari SM, Rosypal AC, Dubey JP. 2008 serological survey for antibodies to Encephalitozoon cuniculi in ownerless dogs from urban areas of Brazil and Colombia. J Parasitol. Oct 21:1. [Epub ahead of print]
  • Lindsay DS, Holliman D, Flick GJ, Goodwin DG, Mitchell SM, Dubey JP. 2008 Effects of high pressure processing on Toxoplasma gondii oocysts on raspberries. J Parasitol. 94(3):757-8.
  • Goodwin DG, Strobl J, Mitchell SM, Zajac AM, Lindsay DS. 2008 Evaluation of the mood-stabilizing agent valproic acid as a preventative for toxoplasmosis in mice and activity against tissue cysts in mice. J Parasitol. 94(2):555-7.
  • Goodwin D, Gennari SM, Howe DK, Dubey JP, Zajac AM, Lindsay DS. 2006. Prevalence of antibodies to Encephalitozoon cuniculi in horses from Brazil. Vet Parasitol. E Pub
  • Lindsay DS, Kaur T, Mitchell SM, Goodwin DG, Strobl J, Dubey JP. 2005. Buprenorphine does not affect acute murine toxoplasmosis and is recommended as an analgesic in Toxoplasma gondii studies in mice. J Parasitol. 91:1488-1490.
  • Reilly CM, Olgun S, Goodwin D, Gogal RM Jr, Santo A, Romesburg JW, Ahmed SA, 2006 Gilkeson GS. Interferon regulatory factor-1 gene deletion decreases glomerulonephritis in MRL/lpr mice. Eur J Immunol. 36:1296-1308.
  • Raffetto JD, Vasquez R, Goodwin DG, Menzoian JO. 2006 Mitogen-activated protein kinase pathway regulates cell proliferation in venous ulcer fibroblasts. Vasc Endovascular Surg. 40:59-66.
  • Vasquez R, Marien BJ, Gram C, Goodwin DG, Menzoian JO, Raffetto JD. 2004 Proliferative capacity of venous ulcer wound fibroblasts in the presence of platelet-derived growth factor. Vasc Endovascular Surg. 38:355-360.

Talks

  • Southern Society of Parasitology. Gatlinburg, Tenn. March 29-31, 2006.
  • Prevalence of antibodies to Encephalitozoon cuniculi in horses from Brazil. David Goodwin, Solange M. Gennari, Daniel K. Howe, J.P. Dubey, Anne M. Zajac, and David S. Lindsay.
  • International Workshop on Opportunistic Protozoa. Lisbon, Portugal June 20-24, 2006.
  • Antibodies prevelence to Encephalitozoon cuniculi in large companion animals, hoses, from Brazil. David Goodwin, Solange M. Gennari, Daniel K. Howe, J.P. Dubey, Anne M. Zajac, and David S. Lindsay.
  • American Association for Veterinary Parasitology. Honolulu, Hawaii July 15-19, 2006. Antibodies prevelence to Encephalitozoon cuniculi in hoses, from Brazil. David Goodwin, Solange M. Gennari, Daniel K. Howe, J.P. Dubey, Anne M. Zajac, and David S. Lindsay.
  • Southern Society of Parasitology. Georgetown, South Carolina April 11-13, 2007. Prevalence of antibodies to Encephalitozoon cuniculi a Microsporidia parasite in South American Dogs. David Goodwin, Anne M Zajac, JP. DUBEY, and David S. Lindsay
  • American Association for Veterinary Parasitology. Washington D.C July 14-17, 2007. Evaluation of the mood stabilizing agent valproic acid as a preventative for toxoplasmosis in mice. David S. Lindsay, David Goodwin, Sheila Mitchell and Jeannine Strobl
  • Southern Society of Parasitology. Spartanburg, South Carolina. April 16-18, 2008
  • The Evaluation of Mood Stabilizing Anti-psychotic Drugs for Anti-parasitic Properties. David G. Goodwin, Jeannine Strobl, Sheila M. Mitchell, Anne M. Zajac, and David S. Lindsay.

Posters

  • Edger Via College of Osteopathic Medicine Research Days. Blacksburg Virginia. October 8, 2007. Evaluation of the mood stabilizing agent Valproic acid as a preventative for toxoplasmosis in mice and activity against tissue cysts in mice. David Goodwin, Jeannine Strobl, Sheila Mitchell, Anne Zajac, David S. Lindsay